Bioactivity:

BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.

CAS nr:

468740-43-4

Purity:

98%

Molecular Weight:

479,96

SMILES:

CC1=C2N=C(NC2=CC(=C1)N1CCOCC1)C1=C(NC[C@@H](O)C2=CC=CC(Cl)=C2)C=CNC1=O

Formula:

C25H26ClN5O3

Pathway:

MAPK,Tyrosine Kinase/Adaptors,Angiogenesis,Angiogenesis,Tyrosine Kinase/Adaptors,Cytoskeletal Signaling,Apoptosis,Tyrosine Kinase/Adaptors

Target:

MEK,Src,Src,FAK,FAK,FAK,Apoptosis,IGF-1R