Bioactivity:

Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis.

CAS nr:

73069-27-9

Purity:

98%

Molecular Weight:

386,4

SMILES:

C\C=C(\C)C(=O)O[C@H]1[C@@H](OC(C)=O)c2c(OC1(C)C)ccc1ccc(=O)oc21

Formula:

C21H22O7

Pathway:

Neuroscience,NF-_b

Target:

CaMK,NF-_B