Bioactivity:

ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively)

CAS nr:

1035072-16-2

Purity:

98%

Molecular Weight:

477,4

SMILES:

COC1=C(C=C(C=C1)N(C(C2=CC=CS2)C(=O)NCCC3=CC=CC=C3)C(=O)CCl)Cl

Formula:

C23H22Cl2N2O3S

Pathway:

Metabolism,oxidation-reduction,Cell Cycle/Checkpoint,Apoptosis

Target:

Glutathione Peroxidase,GPX,Ferroptosis,Ferroptosis