Bioactivity:

A-9758 is a ROR_ ligand and a selective ROR_t inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 drive

CAS nr:

2055271-22-0

Purity:

98%

Molecular Weight:

527,36

SMILES:

O=C(C1CCN(C(C2=CC=C(Cl)C(CC(N3C)=CC4=C3C=C(C(F)(F)F)C=C4C)=C2Cl)=O)CC1)O

Formula:

C25H23Cl2F3N2O3

Pathway:

Metabolism

Target:

ROR