Bioactivity:

Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activate macrocyclic Mcl-1 inhibitor (Ki= 0.061 nM;�IC50=19 nM in an OPM-2 cell viability assay).

CAS nr:

2376774-73-9

Purity:

98%

Molecular Weight:

820,38

SMILES:

ClC1=CC(CCC2)=C(C=C1)[C@]2(CO3)CN(C[C@H]4[C@@H](CC4)[C@@H](OCCN5CC(F)(F)C5)/C=C/CCN(C)C6=O)C7=C3C=CC([C@@](O)(C(NS(=O)(N(C)C)=O)=O)C6)=C7

Formula:

C40H52ClF2N5O7S

Pathway:

Apoptosis

Target:

BCL