Bioactivity:

LY411575, a potent _-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage with IC50 of 0.39 nM.

CAS nr:

209984-57-6

Purity:

98%

Molecular Weight:

479,48

SMILES:

C[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)N[C@H]1c2ccccc2-c2ccccc2N(C)C1=O

Formula:

C26H23F2N3O4

Pathway:

Stem Cells,Proteases/Proteasome,Neuroscience,Apoptosis

Target:

Gamma-secretase,Gamma-secretase,Gamma-secretase,Apoptosis