Bioactivity:

AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.

CAS nr:

1233339-22-4

Purity:

98%

Molecular Weight:

412,51

SMILES:

C[C@@H]1COCCN1c1cc(nc(n1)-c1cccc2[nH]ccc12)C1(CC1)S(C)(=O)=O

Formula:

C21H24N4O3S

Pathway:

PI3K/Akt/mTOR signaling,PI3K/Akt/mTOR signaling,DNA Damage/DNA Repair

Target:

mTOR,ATM/ATR,ATM/ATR