Bioactivity:

AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.

CAS nr:

473719-41-4

Purity:

98%

Molecular Weight:

603,59

SMILES:

O=C(N([C@@H](C1=NC2=NC=CC=C2C(N1C3=CC=C(OCC)C=C3)=O)C)CC4=CC=CN=C4)CC5=CC=C(OC(F)(F)F)C=C5

Formula:

C32H28F3N5O4

Pathway:

Autophagy,Immunology/Inflammation,GPCR/G Protein

Target:

CXCR,CXCR,CXCR