Bioactivity:

PF-06278121 is a potent and selective Trk inhibitor. PF-06278121 shows Trk A/B IC50 = 4/94 nM (enzymatic assay), Trk A/B/C IC50 = 13/7/6 nM (PathHunter cell assay).

CAS nr:

1402438-37-2

Purity:

98%

Molecular Weight:

483,45

SMILES:

O=C(C1=CN=CC(NC(CC2=CC=C(C=C2)C(F)(F)F)=O)=C1)C3=CN(C4=C3C=NC=N4)[C@H](CO)C

Formula:

C24H20F3N5O3

Pathway:

Target: