Bioactivity:

ICI 216140 is a GRP/bombesin receptor 2 antagonist (IC50: 2 nM in vitro). At 2 mg/kg, it can decrease bombesin-stimulated pancreatic amylase secretion in rats. At 1 mM, it has been proved to attenuate bombesin-stimulated increases in blood pressure in rat

CAS nr:

124001-41-8

Purity:

98%

Molecular Weight:

916,09

SMILES:

CC(C)C[C@@H](C(N)=O)N(C([C@H](CC1=CNC=N1)NC([C@@H](C)NC([C@H](C(C)C)NC([C@H](C)NC([C@H](CC2=CNC3=C2C=CC=C3)NC([C@H](CC4=CNC=N4)NC(C(C)C)=O)=O)=O)=O)=O)=O)=O)C

Formula:

C45H65N13O8

Pathway:

Target: