Bioactivity:

Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase, PDGFR_, and Flt1 (IC50s: 7 nM, 3 n

CAS nr:

1847485-91-9

Purity:

98%

Molecular Weight:

525

SMILES:

O=C(NC1=CC=CC(F)=C1)NC2=CC=C(C3=CSC4=C3C(N)=NC=C4C5=CN(CCO)N=C5)C=C2.[H]Cl

Formula:

C25H22ClFN6O2S

Pathway:

Chromatin/Epigenetic,Cell Cycle/Checkpoint

Target:

Aurora Kinase,Aurora Kinase