Bioactivity:

BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.

CAS nr:

859853-30-8

Purity:

98%

Molecular Weight:

368,43

SMILES:

COc1cc(Nc2ncnn3c2c(CN(CC[C@H]2N)C[C@H]2O)cc3)ccc1

Formula:

C19H24N6O2

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis,JAK/STAT signaling,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Angiogenesis,JAK/STAT signaling

Target:

HER,HER,HER,VEGFR,VEGFR,EGFR,EGFR,EGFR