Bioactivity:

Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Isoangustone A dampens mesangial sclerosi

CAS nr:

129280-34-8

Purity:

98%

Molecular Weight:

422,47

SMILES:

CC(C)=CCc1cc(cc(O)c1O)-c1coc2cc(O)c(CC=C(C)C)c(O)c2c1=O

Formula:

C25H26O6

Pathway:

Cell Cycle/Checkpoint,Immunology/Inflammation,PI3K/Akt/mTOR signaling,MAPK,Proteases/Proteasome,Stem Cells,PI3K/Akt/mTOR signaling,Cytoskeletal Signaling,PI3K/Akt/mTOR signaling,NF-_b

Target:

CDK,ROS,PI3K,JNK,MMP,GSK-3,GSK-3,Akt,Akt,NF-_B