Bioactivity:

PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.

CAS nr:

194423-15-9

Purity:

98%

Molecular Weight:

369,22

SMILES:

C=CC(=O)Nc1cc2c(cc1)ncnc2Nc1cc(ccc1)Br

Formula:

C17H13BrN4O

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,Tyrosine Kinase/Adaptors,Angiogenesis,Angiogenesis,JAK/STAT signaling,Autophagy,Tyrosine Kinase/Adaptors,Apoptosis,Tyrosine Kinase/Adaptors,Cytoskeletal Signaling,Chromatin/Epigenetic

Target:

PDGFR,PDGFR,FGFR,FGFR,EGFR,EGFR,Autophagy,EGFR,Apoptosis,IGF-1R,PKC,PKC