Bioactivity:

AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor (IC50: 18 nM; Kd: 2.9 nM) with inhibitory to mammary tumor growth. AZ12601011 inhibits phosphorylation of SMAD2 via selectively inhibiting TGFBR1, ALK4, and ALK7.

CAS nr:

T10426

Purity:

98%

Molecular Weight:

313,36

SMILES:

C1(C2=NC=CC=C2)=NC(N3C=CC4=C3C=CN=C4)=C(CCC5)C5=N1

Formula:

C19H15N5

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis

Target:

ALK,ALK