Bioactivity:

GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3K_ and other 266 kinases. Phase 1.

CAS nr:

1207360-89-1

Purity:

98%

Molecular Weight:

452,55

SMILES:

CCNC(=O)NC1=CC=C(C=C1)C1=NC(N2CCOC[C@@H]2C)=C2CCN(CC2=N1)C1COC1

Formula:

C24H32N6O3

Pathway:

PI3K/Akt/mTOR signaling,PI3K/Akt/mTOR signaling,Autophagy

Target:

mTOR,PI3K,Autophagy