Bioactivity:

PR-924 is a selective inhibitor of tripeptide epoxyketone immunoproteasome subunit LMP-7 (IC50: 22 nM). PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cells. PR-924 has antitumor activities. PR-924 covalently modifies proteasomal N

CAS nr:

1416709-79-9

Purity:

98%

Molecular Weight:

618,72

SMILES:

O=C(N[C@@H](CC1=CC=CC=C1)C([C@]2(CO2)C)=O)[C@@H](NC([C@@H](C)NC(C(CC3=CC=CC=C43)=C4C)=O)=O)CC5=CNC6=CC=CC=C56

Formula:

C37H38N4O5

Pathway:

Proteases/Proteasome,Ubiquitination

Target:

Proteasome,Proteasome