Bioactivity:

AZ-4217 is a high potency BACE inhibitor. It displays acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice. AZ-4217 has IC50 160 pM in human SH-SY5Y cells with an excellent in vivo efficacy.

CAS nr:

1383846-83-0

Purity:

98%

Molecular Weight:

476,56

SMILES:

FC1=C2C([C@@](C(C=C3C)=CN(CC)C3=O)(C4=CC(C5=CN=CC(C#CC)=C5)=CC=C4)N=C2N)=CC=C1

Formula:

C30H25FN4O

Pathway:

Target: