Bioactivity:

EGFR-IN-8 can be a promising candidate for further development to target EGFR TKI-resistant NSCLC.�EGFR-IN-8 is a dual EGFR and c-Met inhibitor.

CAS nr:

2407957-87-1

Purity:

98%

Molecular Weight:

662,02

SMILES:

O=C(NC1=CC(C(F)(F)F)=C(NC(C2CC2)=O)C=C1)NC3=CC=CC(C4=NC(C5=CC=C(NC(C6=CC=CN=C6)=O)C=C5Cl)=NO4)=C3

Formula:

C32H23ClF3N7O4

Pathway:

Tyrosine Kinase/Adaptors,Tyrosine Kinase/Adaptors,Angiogenesis,JAK/STAT signaling

Target:

c-Met/HGFR,EGFR,EGFR,EGFR