Bioactivity:

QO-58 is a Kv7 channel opener with EC50 values of 7.0, 1.0, 5.2, 0.6 _M for Kv7.1, Kv7.2, Kv7.3/7.5, Kv7.4 respectively. QO-58 increases the pain threshold of neuropathic pain in a sciatic nerve CCI in vivo.

CAS nr:

1259536-62-3

Purity:

98%

Molecular Weight:

443,18

SMILES:

O=C1C=C(C2=CC(F)=C(Cl)N=C2Cl)N=C3N1NC(C(F)(F)F)=C3C4=CC=CC=C4

Formula:

C18H8Cl2F4N4O

Pathway:

Target: