Bioactivity:

Sunitinib is an indolinone-based tyrosine kinase inhibitor. It blocks the tyrosine kinase activities of VEGFR2, PDGFR_ (IC50: 80/2 nM), and c-kit.

CAS nr:

341031-54-7

Purity:

98%

Molecular Weight:

532,56

SMILES:

O[C@@H](CC(O)=O)C(O)=O.CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C

Formula:

C26H33FN4O7

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,Tyrosine Kinase/Adaptors,Angiogenesis,Autophagy,Apoptosis,Cell Cycle/Checkpoint,Tyrosine Kinase/Adaptors,Autophagy,Angiogenesis,Tyrosine Kinase/Adaptors

Target:

PDGFR,PDGFR,VEGFR,VEGFR,Autophagy,Apoptosis,IRE1,c-Kit,Mitophagy,FLT,FLT