Bioactivity:

JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs.

CAS nr:

2300106-50-5

Purity:

98%

Molecular Weight:

448,47

SMILES:

O=S(N[C@H](C[C@@H]1NC#N)C(C1=C2)=CC=C2C3=C4C(NC=C4)=NC=N3)(C5=CC=CC(F)=C5)=O

Formula:

C22H17FN6O2S

Pathway:

Stem Cells,Angiogenesis,JAK/STAT signaling,Chromatin/Epigenetic

Target:

JAK,JAK,JAK,JAK