RO8994 T3517
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Specifications
| 1mg/5mg/10mg/25mg/50mg/100mg |
Bioactivity:
RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays).
CAS nr:
1309684-94-3
Purity:
98%
Molecular Weight:
613,51
SMILES:
O=C([C@@H]1N[C@@H](CC(C)(C)C)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1c2ccc(Cl)c1)Nc1ccc(C(=O)N)cc1OC
Formula:
C31H31Cl2FN4O4
Pathway:
Apoptosis,Ubiquitination,Apoptosis
Target:
Mdm2,E1/E2/E3 Enzyme,p53