Bioactivity:

INCB-28060(free base) is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinas

CAS nr:

1197376-85-4

Purity:

98%

Molecular Weight:

485,34

SMILES:

Cl.Cl.CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1

Formula:

C23H19Cl2FN6O

Pathway:

Tyrosine Kinase/Adaptors

Target:

c-Met/HGFR