Bioactivity:

PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.

CAS nr:

942487-16-3

Purity:

98%

Molecular Weight:

474,48

SMILES:

CC(=O)NCC(=O)N1[C@H]2CC[C@@H]1C3=C2C=CC(=C3)NC4=NC=C(C(=N4)NC5CCC5)C(F)(F)F

Formula:

C23H25F3N6O2

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,Tyrosine Kinase/Adaptors,Angiogenesis,Chromatin/Epigenetic,Cell Cycle/Checkpoint,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Cytoskeletal Signaling

Target:

FLT,FLT,VEGFR,VEGFR,Aurora Kinase,Aurora Kinase,Trk receptor,FAK,FAK,FAK