Bioactivity:

Dxd (Exatecan derivative for ADC) is a potent inhibitor of DNA topoisomerase I (IC50: 0.31 _M). It is used as a conjugated drug of HER2-targeting ADC.

CAS nr:

1599440-33-1

Purity:

98%

Molecular Weight:

493,48

SMILES:

O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5NC(CO)=O)C(C)=C(F)C=C6N=C4C3=C2)=O

Formula:

C26H24FN3O6

Pathway:

DNA Damage/DNA Repair

Target:

Topoisomerase