Bioactivity:

PNZ5 is a potent and isoxazole-based pan-BET inhibitor, with high selectivity and potency similar to the well-established (+)-JQ1, with a KD of 5.43 nM for BRD4(1).

CAS nr:

1629277-36-6

Purity:

98%

Molecular Weight:

318,37

SMILES:

CN1C(C2=CC=C(C3=C(C)ON=C3C)C=C2[C@@]1(C4=CC=CC=C4)[H])=O

Formula:

C20H18N2O2

Pathway:

Chromatin/Epigenetic

Target:

Epigenetic Reader Domain