Bioactivity:

Flavopiridol (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4, 6 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Phase 1/2.

CAS nr:

146426-40-6

Purity:

98%

Molecular Weight:

401,84

SMILES:

[H][C@@]1(CCN(C)C[C@H]1O)C1=C2OC(=CC(=O)C2=C(O)C=C1O)C1=C(Cl)C=CC=C1

Formula:

C21H20ClNO5

Pathway:

Proteases/Proteasome,Microbiology/Virology,Autophagy,Apoptosis,Cell Cycle/Checkpoint

Target:

HIV Protease,HIV Protease,Autophagy,Apoptosis,CDK