Bioactivity:

AMG-47a is a potent inhibitor of Lck and T cell proliferation.�AMG-47a could promote the degradation of the KRAS oncoprotein.�AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.

CAS nr:

882663-88-9

Purity:

98%

Molecular Weight:

535,56

SMILES:

Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1

Formula:

C29H28F3N5O2

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis,JAK/STAT signaling,Chromatin/Epigenetic,Stem Cells,Angiogenesis,Tyrosine Kinase/Adaptors,Angiogenesis,MAPK

Target:

VEGFR,VEGFR,JAK,JAK,JAK,JAK,Src,Src,p38 MAPK