Bioactivity:

Pico145 is a remarkable inhibitor of TRPC1/4/5 channels. Pico145 inhibits (_)-englerin A-activated TRPC4/TRPC5 channels (IC50s: 0.349 and 1.3 nM in cells) It also shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8.

CAS nr:

1628287-16-0

Purity:

98%

Molecular Weight:

524,88

SMILES:

CN(c1c(C(N2CCCO)=O)n(Cc(cc3)ccc3Cl)c(Oc3cc(OC(F)(F)F)ccc3)n1)C2=O

Formula:

C23H20ClF3N4O5

Pathway:

Membrane transporter/Ion channel

Target:

TRP/TRPV Channel