Bioactivity:

Regorafﾎnib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFR_, RET, Kit, and Raf-1 (IC50s: 13/4.2/46, 1.5, 22, 7, and 2.5 nM).

CAS nr:

835621-11-9

Purity:

98%

Molecular Weight:

498,81

SMILES:

CNC(=O)C1=[N+](C=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F)[O-]

Formula:

C21H15ClF4N4O4

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,MAPK,Tyrosine Kinase/Adaptors,Apoptosis,Tyrosine Kinase/Adaptors,Angiogenesis,Metabolism,Tyrosine Kinase/Adaptors

Target:

PDGFR,PDGFR,Raf,c-RET,c-RET,VEGFR,VEGFR,Drug Metabolite,c-Kit