Bioactivity:

Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. Vactosertib Hydrochloride also inhibits ALK2 and ALK4 (IC50: 17.3 nM).

CAS nr:

1352610-25-3

Purity:

98%

Molecular Weight:

435,88

SMILES:

CC1=CC=CC(C2=C(C3=CN4C(C=C3)=NC=N4)NC(CNC5=CC=CC=C5F)=N2)=N1.Cl

Formula:

C22H19ClFN7

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis

Target:

ALK,ALK