Bioactivity:

AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC

CAS nr:

185991-24-6

Purity:

98%

Molecular Weight:

410,6

SMILES:

C1(CNCC2=CC=C(CN3CCNCCCNCCNCCC3)C=C2)=NC=CC=C1

Formula:

C24H38N6

Pathway:

Proteases/Proteasome,Microbiology/Virology

Target:

HIV Protease,HIV Protease