Bioactivity:

Pemetrexed Disodium Hydrate is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Disodium Hydrate for TS, DHFR and GARFT is 1.3 nM, 7.2 nM and 65 nM, respectively.

CAS nr:

357166-30-4

Purity:

98%

Molecular Weight:

516,42

SMILES:

O.O.O.O.O.[Na+].[Na+].[Na+].[Na+].Nc1nc(=O)c2c(CCc3ccc(cc3)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)c[nH]c2[nH]1.Nc1nc(=O)c2c(CCc3ccc(cc3)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)c[nH]c2[nH]1

Formula:

C20H21N5O6�5/2H2O�2Na

Pathway:

DNA Damage/DNA Repair,Metabolism,Cell Cycle/Checkpoint,Autophagy,Cell Cycle/Checkpoint,Apoptosis,DNA Damage/DNA Repair,Cell Cycle/Checkpoint

Target:

DHFR,DHFR,DHFR,Autophagy,Antifolate,Apoptosis,DNA/RNA Synthesis,DNA/RNA Synthesis