Bioactivity:

ATR inhibitor 2 is an orally active, ATP-competitive, and selective ATR inhibitor (Ki <150 pM) with antitumor activity. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation (IC50: 8 nM).

CAS nr:

1613191-99-3

Purity:

98%

Molecular Weight:

541,55

SMILES:

O=C(C1=C2N=CC(F)=CN2N=C1N)NC3=C(N4CCC(C(N5CCN(C6COC6)CC5)=O)CC4)C(F)=CN=C3

Formula:

C25H29F2N9O3

Pathway:

DNA Damage/DNA Repair,PI3K/Akt/mTOR signaling

Target:

ATM/ATR,ATM/ATR