Bioactivity:

R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-_ type I receptor inhibitor.

CAS nr:

879487-87-3

Purity:

98%

Molecular Weight:

363,39

SMILES:

CC1=NC(=CC=C1)C1=NNC=C1C1=CC(C2=CN(CCO)N=C2)=C(F)C=C1

Formula:

C20H18FN5O

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis,Stem Cells

Target:

ALK,ALK,TGF-beta/Smad