Bioactivity:

TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).

CAS nr:

1848959-11-4

Purity:

98%

Molecular Weight:

542,97

SMILES:

NC1=NC=NC2=C1C(C#CC3=C(F)C=CC=C3OCC)=CN2[C@@H]4O[C@H](CNS(=O)(N)=O)[C@@H](O)[C@H]4O.Cl

Formula:

C21H24ClFN6O6S

Pathway:

Metabolism,Ubiquitination

Target:

NEDD8,E1/E2/E3 Enzyme