Bioactivity:

IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 _M, 0.072 _M, and 1.38 _M for IDH1R132H, IDH1R132C, and IDH1wt).

CAS nr:

1429179-07-6

Purity:

98%

Molecular Weight:

436,48

SMILES:

O=C1OC[C@H](C(C)C)N1C2=NC(N[C@H](C3=NC=C(C4=CC=C(F)C(C)=C4)C=N3)C)=NC=C2

Formula:

C23H25FN6O2

Pathway:

Others

Target:

Others