Bioactivity:

PHPS1 is an inhibitor of Shp2. PHPS1 efficiently inhibits activation of Erk1/2 by the leukemia-associated Shp2 mutant, Shp2-E76K, and blocks the anchorage-independent growth of a variety of human tumor cell lines.

CAS nr:

314291-83-3

Purity:

98%

Molecular Weight:

465,44

SMILES:

[O-][N+](Cc(cc1)ccc1C(NN(C1=O)c2ccccc2)=C1N=Nc1ccc(CS(O)(=O)=O)cc1)=O

Formula:

C21H15N5O6S

Pathway:

Metabolism

Target:

Phosphatase