Bioactivity:

ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold more selective for Aurora A than Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and P

CAS nr:

1291074-87-7

Purity:

98%

Molecular Weight:

525,56

SMILES:

O[C@@H]([C@H](O)C(O)=O)C(O)=O.CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(\C=C\c2ccccc2)n1

Formula:

C25H31N7O6

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Apoptosis,Tyrosine Kinase/Adaptors,Chromatin/Epigenetic,Cell Cycle/Checkpoint,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Angiogenesis,Apoptosis

Target:

PDGFR,PDGFR,FLT,FLT,VEGFR,c-RET,c-RET,VEGFR,Aurora Kinase,Aurora Kinase,Src,Src,FGFR,FGFR,Apoptosis