Bioactivity:

DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4_, but does not alter PRMT5 expression. Anti-cancer activity.DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 17 nM.

CAS nr:

2243709-60-4

Purity:

98%

Molecular Weight:

512,64

SMILES:

CN(C)C1=CC=C(C(N2CCC(C=C(C(NCC(O)CN3CC(C=CC=C4)=C4CC3)=O)C=C5)=C5C2)=O)C=C1

Formula:

C31H36N4O3

Pathway:

Chromatin/Epigenetic

Target:

Histone Methyltransferase