Bioactivity:

Dactolisib Tosylate (BEZ235 Tosylate) is an inhibitor of dual PI3K and mTOR kinase(IC50 values of 4, 75, 7, 5 nM for PI3K_, _, _, _, respectively). Dactolisib Tosylate also inhibits mTORC1 and mTORC2.

CAS nr:

1028385-32-1

Purity:

98%

Molecular Weight:

641,74

SMILES:

CN(C1=C2C3=CC(C4=CC5=CC=CC=C5N=C4)=CC=C3N=C1)C(N2C6=CC=C(C=C6)C(C)(C#N)C)=O.CC7=CC=C(S(=O)(O)=O)C=C7

Formula:

C37H31N5O4S

Pathway:

PI3K/Akt/mTOR signaling,PI3K/Akt/mTOR signaling,Autophagy

Target:

mTOR,PI3K,Autophagy