Bioactivity:

Trametinib is an ATP-noncompetitive inhibitor of MEK 1/2 (IC50s: 0.7/0.9 nM). It shows low inhibition for more than 180 kinases, including B-Raf, c-Raf, and MEK5.

CAS nr:

871700-17-3

Purity:

98%

Molecular Weight:

615,39

SMILES:

CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O

Formula:

C26H23FIN5O4

Pathway:

MAPK,Autophagy,Apoptosis

Target:

MEK,Autophagy,Apoptosis