Bioactivity:

PAT-505 is a selective, noncompetitive and orally available inhibitor of autotaxin(IC50 of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma).

CAS nr:

1782070-22-7

Purity:

98%

Molecular Weight:

473,92

SMILES:

O=C(O)C1=CC=CC(SC2=C(C3CC3)N(C4=CN(CC)N=C4)C5=C2C=CC(Cl)=C5F)=C1F

Formula:

C23H18ClF2N3O2S

Pathway:

Metabolism

Target:

PDE