Bioactivity:

Tazemetostat hydrobromide is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 (Ki: 2.5 nM). Tazemetostat hydrobromide also inhibits EZH1 (IC50: 3

CAS nr:

1467052-75-0

Purity:

98%

Molecular Weight:

653,65

SMILES:

O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C(C)C=C(C)NC5=O.[H]Br

Formula:

C34H45BrN4O4

Pathway:

Chromatin/Epigenetic

Target:

Histone Methyltransferase