Bioactivity:

KDM5A-IN-1 is a potent and orally bioavailable inhibitor of pan-histone lysine demethylases 5 (IC50s: 45 nM, 56 nM, and 55 nM for KDM5A, KDM5B, and KDM5C) and (EC50: 960 nM for PC9 H3K4Me3). KDM5A-IN-1 is obviously less effective against other KDM5B enzym

CAS nr:

1905481-36-8

Purity:

98%

Molecular Weight:

290,36

SMILES:

O=C(C1CC1)N[C@@H]2CCN(C(C3=CC(C(C)C)=NN3)=O)C2

Formula:

C15H22N4O2

Pathway:

Chromatin/Epigenetic

Target:

Histone Demethylase