Bioactivity:

MSC 2032964A is a potent selective ASK1 inhibitor (IC50 = 93 nM) that is oral bioavailable and brain permeable. It inhibited neuroinflammation in mouse EAE models and blocked LPS-induced phosphorylation of ASK1 and p38 in cultured mouse astrocytes.

CAS nr:

1124381-43-6

Purity:

98%

Molecular Weight:

362,32

SMILES:

O=C(C1=CC=CN=C1)NC2=NN3C(NC4CC4)=CC(C(F)(F)F)=CC3=N2

Formula:

C16H13F3N6O

Pathway:

Apoptosis

Target:

ASK