Bioactivity:

UNC0224 is inactive against SET7/9, SET8/PreSET7, PRMT3, and JMJD2E. UNC0224 is a potent and selective histone methyltransferase G9a inhibitor (Ki: 2.6 nM, an IC50 of 15 nM, and a Kd of 23 nM). UNC0224 also potently inhibits b>GLP (assay-dependent IC50: 2

CAS nr:

1197196-48-7

Purity:

98%

Molecular Weight:

485,67

SMILES:

CN1CCC(NC2=C3C=C(OC)C(OCCCN(C)C)=CC3=NC(N4CCN(C)CCC4)=N2)CC1

Formula:

C26H43N7O2

Pathway:

Chromatin/Epigenetic

Target:

Histone Methyltransferase