Bioactivity:

GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4). It is used in research for the treatment of pulmonary edema associated with congestive heart failure.

CAS nr:

1419609-94-1

Purity:

98%

Molecular Weight:

460,53

SMILES:

N#CC1=CC=C2N=CN(C[C@](CCC3)(C)C[C@@]43CN(C5=NC=C(C(C)(O)C)N=C5)C(O4)=O)C2=C1

Formula:

C25H28N6O3

Pathway:

Membrane transporter/Ion channel

Target:

TRP/TRPV Channel