Bioactivity:

SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 _M.�It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade.�The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-

CAS nr:

1259484-97-3

Purity:

98%

Molecular Weight:

394,43

SMILES:

O=C(C1=CC(C2=CC=C(OC)C=C2)=NN1)N/N=C(C3=CC=C(OC)C(OC)=C3)\C

Formula:

C21H22N4O4

Pathway:

GPCR/G Protein,Apoptosis

Target:

S1P Receptor,Apoptosis